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Effect of Protein Synthesis Inhibition on the Induction of Cell Lysis in Escherichia coli by Mecillinam plus Nocardicin A

By José Berenguer, Miguel A. de Pedro and David Vázquez


Cell lysis can be induced in Escherichia coli by the combined use of the β-lactam antibiotics nocardicin A and mecillinam. Apparently, the induction of cell lysis occurs by a sequential mechanism in which mecillinam acts first, and nocardicin A has a triggering action insensitive to the inhibition of protein synthesis

Topics: Mechanisms of Action: Physiological Effects
Year: 1982
OAI identifier: oai:pubmedcentral.nih.gov:185724
Provided by: PubMed Central
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