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Plasmid-mediated tetracycline resistance in Haemophilus ducreyi.

By W L Albritton, I W Maclean, L A Slaney, A R Ronald and H G Deneer


Clinical isolates of Haemophilus ducreyi were shown to be resistant to tetracycline. Resistance was associated in some strains with a 30-megadalton plasmid capable of transferring resistance in conjugative matings with other strains of H. ducreyi and other species of Haemophilus. Restriction endonuclease digestion patterns suggest a relationship between H. ducreyi plasmids and other tetracycline resistance plasmids in Haemophilus. The presence of plasmid-mediated resistance to the tetracyclines limits the use of these agents for the treatment of chancroid

Topics: Research Article
Year: 1984
DOI identifier: 10.1128/aac.25.2.187
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Provided by: PubMed Central
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