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Mutation frequency of Haemophilus influenzae to rifampin resistance.

By P M Mendelman, M C Roberts and A L Smith


Twenty-two susceptible strains of Haemophilus influenzae were examined for mutation to rifampin resistance (minimal inhibitory concentration, greater than or equal to 10 micrograms/ml). All strains had detectable apparent mutation frequencies with a median minimal inhibitory concentration 2,000-fold greater than that of their wild-type parents. Of the type b strain mutants, 80% (8 of 10) expressed high-level resistance (minimal inhibitory concentration, 750 micrograms/ml) that was 75-fold greater than readily achievable serum concentrations

Topics: Research Article
Year: 1982
OAI identifier: oai:pubmedcentral.nih.gov:183781
Provided by: PubMed Central
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