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Mezlocillin Enteral Absorption in Rabbits

By Kevin J. Lavelle, Michael E. Brier and George R. Aronoff


To determine the role of enterohepatic recirculation on its nonlinear elimination, we studied the enteral absorption of mezlocillin in rabbits. Mezlocillin was not substantially absorbed from the stomach or duodenum. We conclude that enterohepatic recirculation does not cause the dose-dependent elimination kinetics of mezlocillin

Topics: Pharmacology and Therapeutics
Year: 1981
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Provided by: PubMed Central
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