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Ornithyl amphotericin methyl ester treatment of experimental candidiasis in rats.

By J N Galgiani and D B VanWyck


After intravenous Candida albicans infection, rats received orinthyl amphotericin methyl ester, amphotericin B, or diluent intravenously. At doses of 0.1 and 0.5 mg/kg, the drugs were equally effective in preventing deaths. However, at doses of 2.0 mg/kg, mortality after treatment with amphotericin B was greater than that after placebo, whereas orinthyl amphotericin methyl ester was fully protective

Topics: Research Article
Year: 1984
DOI identifier: 10.1128/aac.26.1.108
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Provided by: PubMed Central
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