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beta-Lactamases and beta-lactam resistance in Escherichia coli.

By G A Jacoby and L Sutton

Abstract

Escherichia coli strains determining 17 different plasmid-determined beta-lactamases were tested for resistance to new broad-spectrum beta-lactam antibiotics. Several beta-lactamases demonstrated enhanced resistance to cefamandole but only low-level resistance to other agents. High production of cloned E. coli chromosomal beta-lactamase, however, provided resistance to cefamandole, cefoxitin, cefotaxime, ceftazidime, and aztreonam but not to BMY-28142 or imipenem

Topics: Research Article
Year: 1985
OAI identifier: oai:pubmedcentral.nih.gov:176364
Provided by: PubMed Central
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