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Elimination of plasmids by new 4-quinolones.

By J Weisser and B Wiedemann


Nalidixic acid and six of the new 4-quinolones eliminated F'lac and various native R plasmids from Escherichia coli at one half or one quarter the MIC. Four of eight plasmids tested were cured by all derivatives, with frequencies from 10 to 98%. Quinolones did not eliminate all plasmids that were cured by novobiocin, and vice versa

Topics: Research Article
Year: 1985
DOI identifier: 10.1128/aac.28.5.700
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Provided by: PubMed Central
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