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MHC class I multimers

By Mei-Yi Sun and Paul Bowness


T lymphocytes play a key role in the immune response to both foreign and self peptide antigens, which they recognize in combination with MHC molecules. In the past it has been difficult to analyse objectively the specificity, frequency and intensity of T cell responses. The recent application of fluorescent-labelled MHC class I multimers, however, has provided a powerful experimental approach to the direct visualisation of antigen-specific T cells. As a result, our perspective of how T cells respond to both viruses and other antigens in vivo has been greatly enhanced

Topics: Technology Review
Publisher: BioMed Central
Year: 2001
DOI identifier: 10.1186/ar315
OAI identifier:
Provided by: PubMed Central

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