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Sigma B Contributes to PrfA-Mediated Virulence in Listeria monocytogenes

By Celine A. Nadon, Barbara M. Bowen, Martin Wiedmann and Kathryn J. Boor


Transcription of the Listeria monocytogenes positive regulatory factor A protein (PrfA) is initiated from either of two promoters immediately upstream of prfA (prfAp(1) and prfAp(2)) or from the upstream plcA promoter. We demonstrate that prfAp(2) is a functional σ(B)-dependent promoter and that a sigB deletion mutation affects the virulence phenotype of L. monocytogenes. Thus, the alternative sigma factor σ(B) contributes to virulence in L. monocytogenes

Topics: Molecular Pathogenesis
Publisher: American Society for Microbiology
Year: 2002
DOI identifier: 10.1128/IAI.70.7.3948-3952.2002
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Provided by: PubMed Central
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