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Magnesium Uptake by CorA Is Essential for Viability of the Gastric Pathogen Helicobacter pylori

By Jens Pfeiffer, Johannes Guhl, Barbara Waidner, Manfred Kist and Stefan Bereswill


We show here that Mg(2+) acquisition by CorA is essential for Helicobacter pylori in vitro, as corA mutants did not grow in media without Mg(2+) supplementation. Complementation analysis performed with an Escherichia coli corA mutant revealed that H. pylori CorA transports nickel and cobalt in addition to Mg(2+). However, Mg(2+) is the dominant CorA substrate, as the corA mutation affected neither cobalt and nickel resistance nor nickel induction of urease in H. pylori. The drastic Mg(2+) requirement (20 mM) of H. pylori corA mutants indicates that CorA plays a key role in the adaptation to the low-Mg(2+) conditions predominant in the gastric environment

Topics: Molecular Pathogenesis
Publisher: American Society for Microbiology
Year: 2002
DOI identifier: 10.1128/IAI.70.7.3930-3934.2002
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Provided by: PubMed Central
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