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Discordance between T-Cell Receptor Expression and Effector Function in Mice Infected with Histoplasma capsulatum

By George S. Deepe, Reta S. Gibbons and Susan R. Ward

Abstract

Vβ10(+) and Vβ14(+) T cells were selectively increased 7 to 14 days following infection in the lungs of naive mice infected with Histoplasma capsulatum. Following secondary challenge of immune mice, Vβ1(+) and Vβ8.1(+) cells were sporadically increased. Elimination of Vβ10(+) and Vβ14(+) cells from naive mice did not alter the course of infection over a period of 21 days. Thus, overexpression of Vβ families does not necessarily signify a key role in host defense

Topics: Fungal and Parasitic Infections
Publisher: American Society for Microbiology
Year: 2002
DOI identifier: 10.1128/IAI.70.3.1648-1652.2002
OAI identifier: oai:pubmedcentral.nih.gov:127812
Provided by: PubMed Central
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