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Antigenic Specificity of the Mycobacterium leprae Homologue of ESAT-6

By John S. Spencer, Maria Angela M. Marques, Monica C. B. S. Lima, Ana Paula Junqueira-Kipnis, Bruce C. Gregory, Richard W. Truman and Patrick J. Brennan

Abstract

The sequence of the Mycobacterium leprae homologue of ESAT-6 shows only 36% amino acid correspondence to that from Mycobacterium tuberculosis. Anti-M. leprae ESAT-6 polyclonal and monoclonal antibodies and T-cell hybridomas reacted only with the homologous protein and allowed identification of the B- and T-cell epitopes. The protein is expressed in M. leprae and appears in the cell wall fraction. Thus, M. leprae ESAT-6 shows promise as a specific diagnostic agent for leprosy

Topics: Microbial Immunity and Vaccines
Publisher: American Society for Microbiology
Year: 2002
DOI identifier: 10.1128/iai.70.2.1010-1013.2002
OAI identifier: oai:pubmedcentral.nih.gov:127711
Provided by: PubMed Central
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