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In Vivo Activities of Farnesyl Pyrophosphate Synthase Inhibitors against Leishmania donovani and Toxoplasma gondii

By Vanessa Yardley, Anis A. Khan, Michael B. Martin, Teri R. Slifer, Fausto G. Araujo, Silvia N. J. Moreno, Roberto Docampo, Simon L. Croft and Eric Oldfield

Abstract

The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani-infected mice but was less effective against T. gondii-infected mice

Topics: Experimental Therapeutics
Publisher: American Society for Microbiology
Year: 2002
DOI identifier: 10.1128/AAC.46.3.929-931.2002
OAI identifier: oai:pubmedcentral.nih.gov:127510
Provided by: PubMed Central
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