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Comparison of Oral Artesunate and Dihydroartemisinin Antimalarial Bioavailabilities in Acute Falciparum Malaria

By Paul N. Newton, Michele van Vugt, Paktiya Teja-Isavadharm, Duangsuda Siriyanonda, Maneerat Rasameesoroj, Pramote Teerapong, Ronatrai Ruangveerayuth, Thra Slight, Francois Nosten, Yupin Suputtamongkol, Sornchai Looareesuwan and Nicholas J. White


Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate

Topics: Pharmacology
Publisher: American Society for Microbiology
Year: 2002
DOI identifier: 10.1128/AAC.46.4.1125-1127.2002
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Provided by: PubMed Central
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