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Functional characterization of the interferon regulatory element in the enhancer 1 region of the hepatitis B virus genome

By Flavio F. Alcantara, Hong Tang and Alan McLachlan

Abstract

An interferon-stimulated response element (ISRE)/interferon regulatory element (IRE) spanning nucleotide coordinates 1091–1100 is present in the enhancer 1/X gene promoter region of the hepatitis B virus (HBV) genome. In the context of a minimal promoter element, the enhancer 1/X gene promoter ISRE/IRE was shown to be a functional regulatory site capable of mediating interferon α- (IFNα) and interferon-stimulated gene factor 3 (ISGF3)-specific transcriptional activation in transient transfection analysis. The enhancer 1/X gene promoter ISRE/IRE was also shown to mediate interferon regulatory factor (IRF) 1 and IRF7 activation of transcription from a minimal promoter construct. In contrast, IFNα and the IRFs had minimal effect on HBV transcription and replication in the context of the viral genome in cell culture

Topics: Article
Publisher: Oxford University Press
Year: 2002
OAI identifier: oai:pubmedcentral.nih.gov:113846
Provided by: PubMed Central
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