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Dependence of Echovirus 9 on the Enterovirus RNA Replication Inhibitor 2-(α-Hydroxybenzyl)-Benzimidazole Maps to Nonstructural Protein 2C

By Dirk Hadaschik, Marcus Klein, Holger Zimmermann, Hans J. Eggers and Birgit Nelsen-Salz

Abstract

HBB [2-(α-hydroxybenzyl)-benzimidazole] selectively inhibits RNA synthesis of most enteroviruses. However, isolation of HBB-dependent variants is possible. Sequence analysis and characterization of recombinant viruses revealed that HBB dependence maps to the nonstructural protein 2C. A single point mutation at position C4782U is sufficient to establish the HBB-dependent phenotype in our echovirus 9 model

Topics: Vaccines and Antiviral Agents
Publisher: American Society for Microbiology
Year: 1999
OAI identifier: oai:pubmedcentral.nih.gov:113111
Provided by: PubMed Central
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