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Identification of Phosphorylation Sites within the Herpes Simplex Virus Tegument Protein VP22

By Gillian Elliott, Dawn O’Reilly and Peter O’Hare

Abstract

The herpes simplex virus protein VP22 is a major phosphoprotein of infected cells. In this study, we identify two serine phosphorylation sites within VP22 and show that the N-terminal site is a substrate for casein kinase II, while the extreme C-terminal site is a substrate for another, as yet unidentified, cellular kinase. Furthermore, we show that a mutant of VP22 which has both sites altered is unable to incorporate phosphate in vivo, confirming that there are no other phosphorylation sites within VP22

Topics: Virus-Cell Interactions
Publisher: American Society for Microbiology
Year: 1999
OAI identifier: oai:pubmedcentral.nih.gov:112693
Provided by: PubMed Central
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