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The Major Open Reading Frame of the β2.7 Transcript of Human Cytomegalovirus: In Vitro Expression of a Protein Posttranscriptionally Regulated by the 5′ Region

By Giovanna Bergamini, Marko Reschke, Maria Concetta Battista, Maria Cristina Boccuni, Fabio Campanini, Alessandro Ripalti and Maria Paola Landini


β2.7 is the major early transcript produced during human cytomegalovirus infection. This abundantly expressed RNA is polysome associated, but no protein product has ever been detected. In this study, a stable peptide of 24 kDa was produced in vitro from the major open reading frame (ORF), TRL4. Following transient transfection, the intracellular localization was nucleolar and the expression was posttranscriptionally inhibited by the 5′ sequence of the transcript, which harbors two short upstream ORFs

Topics: Animal Viruses
Publisher: American Society for Microbiology
Year: 1998
OAI identifier:
Provided by: PubMed Central
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