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Pseudomonas aeruginosa ExoT Is a Rho GTPase-Activating Protein

By Rebecca Krall, Gudula Schmidt, Klaus Aktories and Joseph T. Barbieri

Abstract

Transient intracellular expression of ExoT in CHO cells stimulated cell rounding and actin reorganization. Biochemical studies showed that ExoT was a GTPase-activating protein for RhoA, Rac1, and Cdc42. Together, these data show that ExoT interferes with Rho signal transduction pathways, which regulate actin organization, exocytosis, cell cycle progression, and phagocytosis

Topics: Molecular and Cellular Pathogenesis
Publisher: American Society for Microbiology
Year: 2000
OAI identifier: oai:pubmedcentral.nih.gov:101576
Provided by: PubMed Central
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