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Epitope Mapping of Neutralizing Botulinum Neurotoxin A Antibodies by Phage Display

By B. P. Mullaney, M. G. Pallavicini and J. D. Marks

Abstract

Single-chain antibodies neutralize activity and bind nonoverlapping epitopes of botulinum A neurotoxin. Two phage display epitope libraries were constructed from the 1.3 kb of binding domain cDNA. The minimal epitopes selected against the single-chain Fv-Fc antibodies correspond to conformational epitopes with amino acid residues 1115 to 1223 (S25), 1131 to 1264 (3D12), and 889 to 1294 (C25)

Topics: Microbial Immunity and Vaccines
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/IAI.69.10.6511-6514.2001
OAI identifier: oai:pubmedcentral.nih.gov:98787
Provided by: PubMed Central
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