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Concurrent Upregulation of Urokinase Plasminogen Activator Receptor and CD11b during Tuberculosis and Experimental Endotoxemia

By Nicole P. Juffermans, Pascale E. P. Dekkers, Annelies Verbon, Peter Speelman, Sander J. H. van Deventer and Tom van der Poll


Patients with tuberculosis had higher expression of monocyte urokinase receptor (uPAR) and CD11b than controls. In vitro, lipoarabinomannan and lipopolysaccharide (LPS) from Escherichia coli shared the ability to enhance uPAR and CD11b expression on monocytes and granulocytes. In healthy volunteers, LPS induced increases in monocyte and granulocyte uPAR and CD11b

Topics: Host Response and Inflammation
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/IAI.69.8.5182-5185.2001
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Provided by: PubMed Central
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