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Dissociation of Infectivity and Pathogenicity in Borrelia burgdorferi

By Venetta Thomas, Juan Anguita, Swapna Samanta, Patricia A. Rosa, Philip Stewart, Stephen W. Barthold and Erol Fikrig

Abstract

Clonal Borrelia burgdorferi N40 (cN40) passaged 75 times in vitro (N40-75) infects mice but does not cause disease. N40-75 passaged 45 times further in vitro (N40-120) was no longer infectious and lacked genes encoded on linear plasmids 38 and 28-1, among other differences. These data suggest that B. burgdorferi cN40, N40-75, and N40-120 have distinct phenotypes that can be used to dissect the genetic elements responsible for pathogenicity and infectivity

Topics: Molecular Pathogenesis
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/IAI.69.5.3507-3509.2001
OAI identifier: oai:pubmedcentral.nih.gov:98321
Provided by: PubMed Central
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