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Heat-Inducible Surface Stress Protein (Hsp70) Mediates Sulfatide Recognition of the Respiratory Pathogen Haemophilus influenzae

By Evamarie Hartmann, Clifford A. Lingwood and Joachim Reidl

Abstract

The in vitro glycolipid binding specificity of clinical strains of nontypeable Haemophilus influenzae is altered to include sulfated glycolipids following a brief heat shock. We have constructed, expressed, and purified a recombinant protein of H. influenzae Hsp70, which showed significant specific binding to sulfated galactolipids in vitro. Furthermore, indirect immunofluorescence demonstrates that Hsp70 proteins are surface exposed in H. influenzae only after heat shock and are contained in the outer membrane protein fractions

Topics: Molecular Pathogenesis
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/IAI.69.5.3438-3441.2001
OAI identifier: oai:pubmedcentral.nih.gov:98307
Provided by: PubMed Central
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