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Intracellular Crystal Formation as a Mechanism of Cytotoxicity in Murine Pulmonary Cryptococcus neoformans Infection

By Marta Feldmesser, Yvonne Kress and Arturo Casadevall


Rod-like crystalline structures formed during eosinophilic Cryptococcus neoformans pneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage

Topics: Fungal and Parasitic Infections
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/IAI.69.4.2723-2727.2001
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Provided by: PubMed Central
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