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Genetic Diversity of Pseudomonas aeruginosa Strains Isolated from Ventilated Patients with Nosocomial Pneumonia, Cancer Patients with Bacteremia, and Environmental Water

By Raymond Ruimy, Emmanuel Genauzeau, Christian Barnabe, Arnaud Beaulieu, Michel Tibayrenc and Antoine Andremont


Random amplified polymorphic DNA typing was used to study the genetic diversity of Pseudomonas aeruginosa strains from (i) ventilated patients with nosocomial pneumonia who were hospitalized in intensive care units, (ii) cases of bacteremia in cancer patients with severe neutropenia, and (iii) rivers and swimming pools. Genetic diversity was determined by three phylogenetic methods and by statistical analysis of population genetics. The population studied undergoes epidemic clonality with a high rate of genetic recombination. P. aeruginosa bacteremia and pneumonia are not caused by specific clones within this species

Topics: Molecular Pathogenesis
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/IAI.69.1.584-588.2001
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Provided by: PubMed Central
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