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Myeloperoxidase Exerts Microbicidal Activity against Mycobacterium tuberculosis

By Violetta Borelli, Elena Banfi, Maria Giovanna Perrotta and Giuliano Zabucchi

Abstract

We investigated the antimycobacterial role of myeloperoxidase (MPO), one of the most abundant granule proteins in human neutrophils. Our data indicate that purified MPO, in the presence of hydrogen peroxide, exerts a consistent killing activity against Mycobacterium tuberculosis H37Rv and against a clinical isolate. The activity is time and dose dependent and requires the presence of chloride ions in the assay medium

Topics: Bacterial Infections
Publisher: American Society for Microbiology
Year: 1999
OAI identifier: oai:pubmedcentral.nih.gov:96719
Provided by: PubMed Central
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