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SprE Levels Are Growth Phase Regulated in a ςS-Dependent Manner at the Level of Translation

By Katherine E. Gibson and Thomas J. Silhavy


SprE regulates ςS levels in response to nutrient availability by promoting ClpXP-mediated degradation. Paradoxically, we observe that SprE is similarly regulated, accumulating preferentially upon starvation. This regulation of SprE levels is ςS dependent, altering SprE synthesis at the level of translation. Thus, we demonstrate that SprE and ςS function within a regulatory feedback loop

Topics: Genetics and Molecular Biology
Publisher: American Society for Microbiology
Year: 2000
OAI identifier:
Provided by: PubMed Central
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