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Effective Combination Therapy for Invasive Pneumococcal Pneumonia with Ampicillin and Intravenous Immunoglobulins in a Mouse Model

By Laetitia De Hennezel, Françoise Ramisse, Patrice Binder, Gilles Marchal and Jean-Michel Alonso


Intranasal immunotherapy for Streptococcus pneumoniae invasive pneumonia with polyvalent immunoglobulins (IVIG) was effective in mice against pneumonia but failed to prevent bacteremia. The combination of subcurative doses of IVIG and of ampicillin was fully protective. Such an approach, successfully applied in the preantibiotic era, offers new perspectives for modern therapies

Topics: Experimental Therapeutics
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/AAC.45.1.316-318.2001
OAI identifier: oai:pubmedcentral.nih.gov:90282
Provided by: PubMed Central
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