Article thumbnail
Location of Repository

Indirect autoregulation of a homeotic Drosophila gene mediated by extracellular signaling.

By F Thüringer and M Bienz

Abstract

Commitments to developmental pathways are often made and maintained in groups of cells. Such commitments are conferred by the products of selector genes, many of which are homeobox genes. Homeobox genes can maintain their expression by directly autoregulating their own transcription. Here, we report a case where positive autoregulation of Ultrabithorax, a homeotic Drosophila gene, is at least partly indirect and mediated by the extracellular signal molecules that are products of the genes wingless and decapentaplegic. Indirect autoregulatory mechanisms may be used to ensure coordinate maintenance of selector gene activity in groups of cells

Topics: Research Article
Year: 1993
DOI identifier: 10.1073/pnas.90.9.3899
OAI identifier: oai:pubmedcentral.nih.gov:46413
Provided by: PubMed Central
Sorry, our data provider has not provided any external links therefore we are unable to provide a link to the full text.

Suggested articles


To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.