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EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract

By Mirella Dottori, Lynne Hartley, Mary Galea, George Paxinos, Mark Polizzotto, Trevor Kilpatrick, Perry F. Bartlett, Mark Murphy, Frank Köntgen and Andrew W. Boyd

Abstract

Members of the Eph family of tyrosine kinase receptors have been implicated in the regulation of developmental processes and, in particular, axon guidance in the developing nervous system. The function of the EphA4 (Sek1) receptor was explored through creation of a null mutant mouse. Mice with a null mutation in the EphA4 gene are viable and fertile but have a gross motor dysfunction, which is evidenced by a loss of coordination of limb movement and a resultant hopping, kangaroo-like gait. Consistent with the observed phenotype, anatomical studies and anterograde tracing experiments reveal major disruptions of the corticospinal tract within the medulla and spinal cord in the null mutant animals. These results demonstrate a critical role for EphA4 in establishing the corticospinal projection

Topics: Biological Sciences
Publisher: The National Academy of Sciences
Year: 1998
OAI identifier: oai:pubmedcentral.nih.gov:23772
Provided by: PubMed Central
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