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Dictyostelium myosin II null mutant can still cap Con A receptors

By Carmen Aguado-Velasco and Mark S. Bretscher


Cross-linked antigens on the surface of a motile cell cap at the trailing end of the cell. In Dictyostelium discoideum, myosin II null mutants have previously been reported to be unable to cap Con A receptors, although they are able to locomote. This finding implicated myosin II as an essential component of the capping mechanism, although not of the machinery for locomotion. Here we show that myosin II null mutants do cap Con A receptors, albeit less efficiently than does wild type. This shows that cap formation is not absolutely dependent on myosin II and that a close mechanistic relationship between capping, particle movement, and cell migration may still exist

Topics: Biological Sciences
Publisher: The National Academy of Sciences of the USA
Year: 1997
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Provided by: PubMed Central
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