Location of Repository

Letters: observations. Plasma adiponectin concentrations are independently predicted by fat insulin sensitivity in women and by muscle insulin sensitivity in men

By Junlong Zhang, Richard I.G. Holt, Sarah H. Wild, Ruth B. Poole, Helen Holt and Christopher D. Byrne

Abstract

Adiponectin is an abundant plasma protein, mainly secreted by adipocytes and closely linked to insulin sensitivity (1–4). Plasma adiponectin independently correlates with insulin sensitivity (5). Since women have greater plasma adiponectin levels than men (5–7), we determined sex-specific differences in associations between plasma adiponectin and tissue-specific insulin sensitivity in skeletal muscle, liver, and fat. <br/>Plasma adiponectin concentrations were measured (intra-assay coefficient of variation &lt;4%) in 28 men and 28 women (6 men and 6 women had impaired glucose tolerance according to World Health Organization criteria). Insulin sensitivity in skeletal muscle, liver, and fat was determined by insulin-mediated whole-body glucose disposal (M values), suppression of hepatic glucose output evaluated during a hyperinsulinemic-euglycemic clamp, and suppression of free fatty acid (FFA)

Topics: RB
Year: 2005
OAI identifier: oai:eprints.soton.ac.uk:26159
Provided by: e-Prints Soton
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://dx.doi.org/10.2337/diac... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.