Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Hau, Andrew M.; Greenwood, Jeffrey A.; Loehr, Christiane V.; Serrill, Jeffrey D.; Proteau, Philip J.; Ganley, Ian G.; McPhail, Kerry L.; Ishmael, Jane E.

research article

oai:discovery.dundee.ac.uk:publications/08a81157-27fd-477d-9620-7eeaf0d67be9

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Authors: Andrew M. Hau
Jeffrey A. Greenwood
Christiane V. Loehr
Jeffrey D. Serrill
Philip J. Proteau
Ian G. Ganley
Kerry L. McPhail
Jane E. Ishmael
Publication date: 5 June 2013
Publisher
Doi

Abstract

Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative of a unique mechanism of action. We report that coibamide A is a more potent and efficacious cytotoxin than was previously appreciated, inducing concentration-and time-dependent cytotoxicity (EC50</p

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Last time updated on 14/03/2016

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