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Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands.

By Saskia BULK, J. Berkhof, N. W. J. Bulkmans, G. D. Zielinski, L. Rozendaal, F. J. van Kemenade, P. J. F. Snijders and C. J. L. M. Meijer


We present the type-distribution of high-risk human papillomavirus (HPV) types in women with normal cytology (n=1467), adenocarcinoma in situ (ACIS) (n=61), adenocarcinoma (n=70), and squamous cell carcinoma (SCC) (n=83). Cervical adenocarcinoma and ACIS were significantly more frequently associated with HPV18 (OR(MH) 15.0; 95% CI 8.6-26.1 and 21.8; 95% CI 11.9-39.8, respectively) than normal cytology. Human papillomavirus16 was only associated with adenocarcinoma and ACIS after exclusion of HPV18-positive cases (OR(MH) 6.6; 95% CI 2.8-16.0 and 9.4; 95% CI 2.8-31.2, respectively). For SCC, HPV16 prevalence was elevated (OR(MH) 7.0; 95% CI 3.9-12.4) compared to cases with normal cytology, and HPV18 prevalence was only increased after exclusion of HPV16-positive cases (OR(MH) 4.3; 95% CI 1.6-11.6). These results suggest that HPV18 is mainly a risk factor for the development of adenocarcinoma whereas HPV16 is associated with both SCC and adenocarcinoma.Peer reviewe

Topics: Adenocarcinoma/epidemiology/etiology/virology, Adolescent, Adult, Carcinoma, Squamous Cell/epidemiology/etiology/virology, Female, Human papillomavirus 16/pathogenicity, Human papillomavirus 18/pathogenicity, Humans, Incidence, Middle Aged, Netherlands/epidemiology, Odds Ratio, Papillomavirus Infections/complications, Risk Factors, Uterine Cervical Neoplasms/epidemiology/etiology/virology, Life sciences :: Genetics & genetic processes, Sciences du vivant :: Génétique & processus génétiques
Year: 2006
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