It is apparent that the challenges facing scientific software developers are quite different from those facing their commercial counterparts. Among these differences are the challenges posed by the complex and uncertain nature of the science. There is also the fact that many scientists have experience of developing their own software, albeit in a very restricted setting, leading them to have unrealistic expectations about software development in a different setting. In this paper, we explore the challenges facing scientific software developers focusing especially on molecular biology. We claim that the nature and practice of\ud molecular biology is quite different from that of the physical sciences and pose different problems to software developers. We do not claim that this paper is the last word on the topic but hope that it serves as the inspiration for further debate
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