Calcium phosphate ceramics such as hydroxyapatite and β-tricalcium phosphate (β -TCP) possess mineral composition that closely resembles that of the bone. Thus, they can be good bone substitutes due to their excellent biocompatibility. Biphasic calcium phosphate is a bone substitute which is a mixture of hydroxyapatite and β-tricalcium phosphate in fixed ratios. Studies have demonstrated the osteoconductive potential of this composition. This case report highlights the clinical use of biphasic calcium phosphate as a bone substitute in periapical surgery with a three years follow up showing. It showed fast and complete periapical healing of a persistent periapical lesion
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