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Viruses, Autophagy Genes, and Crohn’s Disease

By Vanessa M. Hubbard and Ken Cadwell

Abstract

The etiology of the intestinal disease Crohn’s disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in this disease remains speculative, accumulating evidence indicate that this possibility requires serious consideration. In this review, we will examine the three-way relationship between viruses, autophagy genes, and Crohn’s disease and discuss how host-pathogen interactions can mediate complex inflammatory disorders

Topics: Crohn’s disease, inflammatory bowel disease, norovirus, MNV, ATG16L1, autophagy, mucosal immunity, intestine, Paneth cells, LCC:Microbiology, LCC:QR1-502, LCC:Science, LCC:Q, DOAJ:Microbiology, DOAJ:Biology, DOAJ:Biology and Life Sciences
Publisher: Molecular Diversity Preservation International
Year: 2011
DOI identifier: 10.3390/v3071281
OAI identifier: oai:doaj.org/article:4639a02fd15e4722b69a0f0cb010693c
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