SMEs play a significant role in the Economic development of the many countries in the world. This research highlighted the role of Small and Medium Enterprises The main objective of current research is to examine the sustainable development through women participation in Small and medium enterprises in upper Sindh. The data were collected from 400 respondents from five Districts Dadu, Nawabshah, Shikarpur, Jacobabad and Kashmore district by using simple random technique. It was further revealed that the rural women is less confident and their husbands were always given them hard time once they are exposing themselves to outside the boundaries of the house. It was revealed the rural women is innovate designs of toppi (Sindhi Caps) as well as other SMEs products which are the only source of earning. They are also paid 70% less value of their products because of lack of marketing and other facilities. The biggest challenges which they were facing they were doing all business in house, lack of marketing facilities, Karo Kari criminal activities and they were deprived from the basic right
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