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Evolução das imunoglobunilas envolvidas na resposta imune de camundongos ao Schistosoma mansoni The evolution of immunoglobulins involved in the immune response to mice infected with Schistosoma mansoni

By Othon de Carvalho Bastos, Humberto de Araújo Rangel, Luiz Augusto Magalhães and Aquiles Eugênico Piedrabuena

Abstract

Foi estudada a evolução das imunoglobulinas envolvidas na resposta imune de camundongos ao Schistosoma mansoni durante oito semanas de infecção, utilizando soros pluri-específicos como reativos biológicos e a técnica da imunoeletroforese bidimensional. Os resultados expressaram modulação da resposta imune humoral, tanto em soros de animais parasitados (I) como nos normais, tomados como controle (C). Aumentos relativos dos níveis de imunoglobulinas entre estes dois grupos foram constatados pela relação I/C. Foi possível verificar o aparecimento de uma resposta primária, ocorrida entre o início da doença e a segunda semana de infecção, constituída de IgM e IgA, e uma secundária, iniciada na sexta semana de infecção, constituída pelas IgA; IgG1 e IgM, com aumentos relativos de 4.5; 3 e 2 vezes normal.<br>The evolution of immunoglobulins involved in the immune response of mice infected with Schistosoma mansoni was studied by using plurispecific sera and the bi-dimensional immunoelectrophoresis technique. Determinations of the level of different immunoglobulins in infected animals and control groups which were mantained under similar conditions detected significant variations in both groups over the 8 weeks of observation. The study of the relationship (I/C) between the level of immunoglobulins of the infected animals (I) and that of corresponding control (C) showed that the infected animals presented a primary response (1-2 weeks after infection date) and a secondary response that was initiated in the 6th week of infection, with levels of IgA, IgG and IgM that were respectively 4.5, 3 and 2 times higher than those of corresponding control

Topics: Schistosoma mansoni, Imunoglobulinas, Esquistossomose mansônica, Schistosoma mansoni, Immunoglobulins, Schistosomiasis, LCC:Public aspects of medicine, LCC:RA1-1270, LCC:Medicine, LCC:R, DOAJ:Public Health, DOAJ:Health Sciences
Publisher: Faculdade de Saúde Pública da Universidade de São Paulo
Year: 1984
DOI identifier: 10.1590/S0034-89101984000200006
OAI identifier: oai:doaj.org/article:7f3f315c482044579b62f1459e6d327b
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