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Insucesso na indução de resistência a drogas esquistossomicidas em uma cepa brasileira humana de Schistosoma mansoni Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni

By Luiz Candido de Souza Dias and Celso Eduardo Olivier

Abstract

No presente estudo, realizou-se uma tentativa de indução de resistência a 3 drogas esquistossomicidas em uma cepa brasileira de S. mansoni, segundo o esquema de indução de resistência tipo II preconizado por JANSMA et al. em 1977. Houve insucesso nas 3 tentativas realizadas. A geração parental tratada com a droga durante o estágio imaturo do verme mostrou-se menos suscetível aos quimioterápicos do que as gerações F1 e F2 do verme. Uma hipótese é levantada para a explicação do fato.<br>In this work, an attempt was made to induceng resistance to 3 schistosomicidal drugs in a Brazilian strain of S. mansoni, according to the Type II resistance induction scheme proposed by JANSMA et al. in 1977. Three attempts were unsuccessful. The parental generation treated with the drug during the immature stage of the worm was less susceptible to the chemotherapeutic agents than generations F1 and F2. A hypothesis is suggested as an explanation

Topics: Schistosomiasis, Schistosoma mansoni, LCC:Medicine (General), LCC:R5-920, LCC:Medicine, LCC:R, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Instituto de Medicina Tropical
Year: 1986
DOI identifier: 10.1590/S0036-46651986000500010
OAI identifier: oai:doaj.org/article:82bfff1b6bbc4295a3038e8047552a77
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