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Microimmunodiffusion test for the serodiagnosis of paracoccidioidomycosis

By Maria Isabel Correa da Silva, Luiz Gastão Chamma and Marcello Franco


We used the micro- and macroimmunodiffusion test for the qualitative and quantitative measurement of anti - P. brasiliensis antibodies in serum of patients with paracoccidioidomycosis. All 103 paracoccidioidomycosis sera (100%) were positive in the micro test versus 87% positivity index in the macrotest. All 83 control sera from patients with other diseases were negative in both tests. Titers of the positive sera tended to be higher in the microtest, which revealed sharper and easier to read precipiting bands. Microimmunodiffusion is simple to be performed, requires a minimum amount of reagents and allows the simultaneous testing of 102 sera. It may replace the macrotest specially in laboratories dealing with great serologic routine

Topics: Paracoccidioidomicose, Microimunodifusão, Arctic medicine. Tropical medicine, RC955-962
Publisher: Universidade de São Paulo
Year: 1989
DOI identifier: 10.1590/S0036-46651989000100008
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