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ACCELERATED PUBLICATION Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties

By Marianne Schimpl, Christina L. Rush, Marie Betou, Ian M. Eggleston, Anneliese D. Recklies and Daan M. F. Van Aalten

Abstract

40 (chitinase 3-like-1) are highly expressed in a number of human cells independent of their origin (mesenchymal, epithelial or haemapoietic). Elevated serum levels of YKL-40 have been associated with a negative outcome in a number of diseases ranging from cancer to inflammation and asthma. YKL-39 expression has been associated with osteoarthritis. However, despite the reported association with disease, the physiological or pathological role of these proteins is still very poorly understood. Although YKL-39 is homologous to the two family 18 chitinases in the human genome, it has been reported to lack any chitinase activity. In the present study, we show that human YKL-39 possesses a chitinase-like fold, but lacks key active-site residue

Year: 2014
OAI identifier: oai:CiteSeerX.psu:10.1.1.417.9374
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