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Using Sequence Homology to Filter High-throughput Protein-protein Interaction Data 1

By Ashwini Patil and Haruki Nakamura


Protein-protein interaction data obtained from high-throughput experiments is thought to have a large number of false positives i.e. interactions that are spurious and do not occur in the cell. This fraction is estimated to be as high as 50 % in yeast [3]. Hence it is important to quantitate the reliability of these interactions and identify those that are true positives i.e. those that actually occur in the cell

Topics: protein-protein interactions, sequence homology, Bayesian approaches, homologous interactions, homologs, Database of Homologous Interactions
Year: 2014
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