Abstract: A study was undertaken to determine the most effective element among the commonly used antimicrobial agents, especially in the body muscle of black tiger shrimp (Penaeus monodon) and giant freshwater prawn (Macrobrachium rosenbergii) on the basis of different chemical interventions. Using 10 ppm calcium hypochlorite, the microbial load has been reduced more significantly (p>0.001) than trisodium phosphate, lactic acid, oxalic acid, sodium carbonate, potassium bicarbonate and acetic acid and as result the total plate count in the Penaeus monodon and Macrobrachium rosenbergii samples reduced by on average of 3.83 (99.53%) and 3.24 (95.5%) log10CFU/g, respectively. Moreover, the aforementioned compound was also found to be very effective against Escherichia coli and Vibrio spp i.e., the count of E. coli and Vibrio spp. reduced to nil or nearly nil. Key words:Reduction of bacteria Chemical interventions Black tiger shrimp (Penaeus monodon) Giant freshwater prawn (Macrobrachium rosenbergii
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