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Electrochemical Interrogation of Interactions between

By Surface-confined Dna, Methylene Blue, Dun Pan, Xiaolei Zuo, Ying Wan, Lihua Wang, Jiong Zhang, Shiping Song and Chunhai Fan

Abstract

Abstract: In this work, we reported a systematic investigation on the interactions between methylene blue (MB) and surface-confined DNA by using electrochemical methods. We demonstrated that the redox potential of MB and binding and dissociation kinetics of MB to DNA differed significantly for single-stranded DNA (ss-DNA) and double-stranded DNA (ds-DNA) immobilized on gold electrodes. This was possibly due to the different binding mechanism between MB and ss- or ds-DNA. This work might provide useful information for developing MB-based sequence-specific electrochemical DNA sensors

Topics: Electrochemical DNA sensors, methylene blue, electrochemical indicators
Year: 2014
OAI identifier: oai:CiteSeerX.psu:10.1.1.415.2720
Provided by: CiteSeerX
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