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© 2009 Molecular Vision Polymorphisms of FCRL3 in a Chinese population with Vogt- Koyanagi-Harada (VKH) syndrome

By Ke Li, Peizeng Yang, Min Zhao, Shengping Hou, Liping Du, Hongyan Zhou, Aize Kijlstra and Sun Yatsen

Abstract

Purpose: The polymorphisms of the Fc receptor-like 3 gene (FCRL3), a novel immunoregulatory gene, have been shown to be associated with certain autoimmune diseases. This study was designed to examine whether the polymorphisms of FCRL3 are associated with susceptibility to Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese population. Methods: A case-control study was performed in 230 Chinese VKH patients and 301 healthy controls. Four single nucleotide polymorphisms (SNPs; −169C/T, −110A/G, +358C/G, and +1381A/G) in FCRL3 were detected using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). human leukocyte antigen-DR4 (HLA-DR4) and HLA-DRw53 genotyping was performed using PCR techniques. Results: The results showed that the frequency of haplotype CACG was significantly lower in patients when compared with that in controls (p=0.0018, corrected p [pc]=0.0288). A significantly higher frequency was found for haplotype CGGG in HLA-DR4 negative patients than in HLA-DR4 negative controls (p=9.94×10 −8, Pc=1.59×10 −6). There were no significant differences in the allele and genotype frequencies of the four investigated SNPs between VKH patients and controls. HLA-DR4 and HLA-DRw53 were significantly associated with VKH syndrome (p=3.21×10 −16 and p=7.08×10 −5, respectively). Stratification analysis according to HLA-DR4 and HLA-DRw53 did not show any association of FCRL3 polymorphisms with VKH syndrome. Conclusions: Our study confirms the previous association of HLA-DR4 and HLA-DRw53 with VKH syndrome but fail

Year: 2014
OAI identifier: oai:CiteSeerX.psu:10.1.1.415.168
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