: Acquired lymphangiectasis is a dilatation of lymphatic vessels that can result as a complication of surgical intervention and radiation therapy for malignancy. Acquired lymphangiectasis shares clinical and histologic features with the congenital lesion, lymphangioma circumscriptum. Diagnosis and treatment of these vesiculo-bullous lesions is important because they may be associated with pain, chronic drainage, and cellulitis. We describe two patients who had these lesions after treatment for cancer and review the pertinent literature. Although a number of treatment options are available, we have found CO 2 laser ablation particularly effective. From the Section of Dermatology, Medical College of Georgia, Augusta. Reprint requests to Frederick W. Gourdin, MD, Section of Dermatology, Medical College of Georgia, 1004 Chafee Ave, Augusta, GA 30912-3190. FIGURE 1. Right axilla shows vesicles and bullae of varying sizes. Some darker lesions contained blood and lymph, while most w..