Skip to main content
Article thumbnail
Location of Repository

Printed in U.S.A. On the Membrane Topology of Vertebrate

By David R. Nelson and Henry W. Strobel

Abstract

Hydropathy profiles of 34 aligned cytochrome P-450 sequences were compared to identify potential trans-membrane segments. Eleven regions with the potential to cross a membrane in at least some P-450 sequences were detected. The known sidedness of several residues and peptides was used to eliminate some of these regions from consideration. Further arguments based membrane-spanning helices of cytochrome P-450 proteins would be a valuable step toward understanding P-450 strucon the location and orientation of the heme relative to ture. With this in mind we have aligned 33 vertebrate P-450 the membrane excluded others. This process of elimisequences and the bacterial P450CIA1 ’ (P-450,.,) sequence nation was continued until only two regions remained. These two segments, present in the first 66 amino acid

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.371.2884
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://citeseerx.ist.psu.edu/v... (external link)
  • http://drnelson.uthsc.edu/topo... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.