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www.mdpi.com/journal/marinedrugs Polyketides from a Marine-Derived Fungus Xylariaceae sp.

By Xu-hua Nong, Zhi-hui Zheng, Xiao-yong Zhang, Xin-hua Lu and Shu-hua Qi

Abstract

Abstract: Eighteen polyketides (1–18) including six citrinin derivatives, two phenol derivatives, one cyclopentenone, two naphthol derivatives, and seven tetralone derivatives were isolated from the culture broth of a marine-derived fungal strain Xylariaceae sp. SCSGAF0086. Five of these compounds (1, 2, 8, 9, and 10) were new, and their structures were determined by spectroscopic methods. Compounds 4, 6, 7, and 17 showed enzyme-inhibitory activities towards several tested enzymes, and 6 and 7 showed strong antifouling activity against Bugula neritina larvae settlement. This is the first time that the antifouling and enzyme-inhibitory activities of these compounds has been reported

Topics: Xylariaceae sp, polyketide, enzyme-inhibitory activity, antifouling activity
Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.362.88
Provided by: CiteSeerX
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