Peptide bond synthesis was performed on PEGA beads under microwave radiations. Classical chemical coupling as well as thermolysin catalyzed synthesis was studied, and the effect of microwave radiations on reaction kinetics, beads ’ integrity, and enzyme activity was assessed. Results demonstrate that microwave radiations can be profitably exploited to improve reaction kinetics in solid phase peptide synthesis when both chemical and biocatalytic strategies are used. Copyright © 2009 Alessandra Basso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The use of microwave (MW) heating has found successful applications in solid phase organic synthesis (SPOS) [1–7]. As far back as 1992, Wang described the use of a single-mode microwave as a heating source to accelerate the chemical coupling  of many amino acids. Reactions on SP often suffer from unsatisfactory reaction kinetics due to slow diffusion. Since microwave energy activates any molecule with dipole moment, a rapid heating at a molecular level i
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